Cane Corso vaccination schedule

A general Cane Corso puppy vaccination schedule by age, with what each vaccine protects against. Schedules for the US, the UK and the EU. Your vet sets the actual one.

DHPP #1
6 to 8 weeks
Protects against distemper, hepatitis (adenovirus), parainfluenza and parvovirus.
Bordetella (if going to puppy class or daycare)
6 to 8 weeks
Protects against kennel cough (Bordetella).
DHPP #2
10 to 12 weeks
Protects against distemper, hepatitis (adenovirus), parainfluenza and parvovirus.
Leptospirosis #1 (at 12 weeks or older)
10 to 12 weeks
Protects against leptospirosis. Core for all dogs in the US since the 2024 AAHA update; core in other regions where the disease is present (WSAVA 2024).
Lyme #1 (regional)
10 to 12 weeks
Protects against Lyme disease, which matters most in tick-heavy areas.
Rabies #1
12 to 16 weeks, as state or local law sets it
Protects against rabies.
DHPP final dose
16 weeks or later
Protects against distemper, hepatitis (adenovirus), parainfluenza and parvovirus.
Leptospirosis #2 (2 to 4 weeks after the first)
16 weeks or later
Protects against leptospirosis. Core for all dogs in the US since the 2024 AAHA update; core in other regions where the disease is present (WSAVA 2024).
Lyme #2 (2 to 4 weeks after the first)
16 weeks or later
Protects against Lyme disease, which matters most in tick-heavy areas.
DHPP booster
12 to 16 months
Protects against distemper, hepatitis (adenovirus), parainfluenza and parvovirus.
Leptospirosis booster
12 to 16 months
Protects against leptospirosis. Core for all dogs in the US since the 2024 AAHA update; core in other regions where the disease is present (WSAVA 2024).
Rabies booster
12 to 16 months
Protects against rabies.
Lyme yearly
12 to 16 months
Protects against Lyme disease, which matters most in tick-heavy areas.
Bordetella yearly
12 to 16 months
Protects against kennel cough (Bordetella).

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Questions

When should my Cane Corso start vaccinations?

Most Cane Corso puppies start their first DHPP between 6 and 8 weeks in the US, or 6 to 9 weeks in the UK and EU. Use the form above with your puppy's age and country to see the next-due date.

When can my Cane Corso start training or guard work?

Foundation training starts after the final puppy vaccination (given at 16 weeks or later), when your vet says protection is in place. Bite-and-jump or pressure work waits until your vet confirms growth is finished, at about 18 months.

Should my Cane Corso get titer testing later?

Many vets offer it for adult giant breeds. Discuss it after the first-year series is complete.

Bordetella for class or daycare?

Yes, if either is in your plan. Most puppy classes and daycares require it.

Same schedule for a Cane Corso mix?

Yes. The core vaccines are the same for purebreds and mixes: DHPP, leptospirosis in the US (AAHA), and rabies where the law or travel requires it. Vaccines such as Lyme and Bordetella depend on lifestyle and region, not breed. The schedule above works for any Cane Corso mix.